![]() ![]() With institutional review board approval (METC97/114 A/mF, 1997), the first series was conducted at Catharina Hospital, Eindhoven, The Netherlands, and Onze-Lieve-Vrouw (OLV) Hospital, Aalst, Belgium, from 1997 to 2000, and recruited 32 patients who were sequentially allocated to receive maintenance phase inhalational general anesthesia with halothane (n = 11), sevoflurane (n = 11), or isoflurane (n = 10). ![]() However, differences in the exact way of measuring this space result in clinically significant different results and, therefore, debate remains about the true value of this measured parameter.Ĭopyright © 2023, StatPearls Publishing LLC.In both series, data were obtained from patients undergoing elective cardiac or thoracic aortic surgery, with no history of acute or chronic respiratory disease, who were recruited with written informed patient consent. Indeed, it may serve as a prognostic factor in patients with acute repository distress syndrome (ARDS) who require ventilation. This phenomenon has clinical significance because, both in healthy and impaired lungs, properly calculating and accounting for this non-physiological space is important for the proper respiratory care of ventilated patients. ![]() This is therefore termed anatomical dead space as it serves no respiratory function. Anatomic dead space is an important phenomenon in respiratory physiology whereby, owing to the fact that upper airways do not function as locations for gas exchange, and because of the tidal nature of ventilation, there is always a fraction of the inspired air that does not perform a physiologic function of exchanging carbon dioxide for oxygen. ![]()
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